Article

Allele-specific alternative polyadenylation links noncoding genetic variation to Alzheimer’s disease risk

2026-02-15

Abstract excerpt

<h4>Background</h4> Alternative polyadenylation (APA) is a crucial post-transcriptional mechanism generating isoform diversity in the nervous system. While genetic variants significantly influence gene expression, the extent to which they regulate 3’ UTR usage in the human brain remains underexplored. We aimed to characterize the landscape of allele-specific alternative polyadenylation (asAPA) and investigate its...

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Literature Corpus work: 2a6525eb-a6fc-54ef-92d1-93564a148720
DOI: 10.64898/2026.02.13.705798

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