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Article

A pcyt-1 allelic series reveals in vivo consequences of reduced phosphatidylcholine synthesis in C. elegans.

G3 (Bethesda, Md.) - 5 Aug 2026

Qvist August, Kaper Delaney, Henricsson Marcus, Stjernman Albin, Borén Jan, Pilon Marc

Abstract excerpt

Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes and is synthesized in part via the rate-limiting enzyme PCYT1A. In humans, hypomorphic PCYT1A variants cause diverse disorders. To define how graded reductions in PC synthesis affect organismal physiology, we generated and characterized a series of mutant alleles in the Caenorhabditis elegans homolog pcyt-1, including variants...

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Alleles
Caenorhabditis elegans
Caenorhabditis elegans Proteins
PC gene
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylcholines

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Open in PubMed Open full text

Identifiers

PMID: 42400359
DOI: 10.1093/g3journal/jkag161
PMCID: PMC13439949

Genes

PC
PCYT1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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