Article
A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis.
Nature communications - 7 May 2026
Li Yan, Huang Siwei, Chan Lam Shing, Li Xuesong, To Ning-Sum, Zhao Xue, Jung Kwangsek, Yang Xingyu, Tse Yu Chung, Xu Ningyi, Xia Yu, Cheung Tom H, Qu Jianan, Mak Ho Yi
Abstract excerpt
The synthesis of glycerolipid is essential to prevent the toxic effects of excess fatty acids. Glycerolipids are generated by the sequential attachment of acyl-CoA to glycerol by endoplasmic reticulum (ER)-localized acyltransferases, ultimately yielding non-toxic triacylglycerol that can be stored in lipid droplets. The key acyltransferase GPAT4 associates with the CHP1 protein, but the regulation of GPAT4...
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