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Article

Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity.

eLife - 26 Nov 2019

Ruiz Mario, Bodhicharla Rakesh, Ståhlman Marcus, Svensk Emma, Busayavalasa Kiran, Palmgren Henrik, Ruhanen Hanna, Boren Jan, Pilon Marc

Abstract excerpt

The human AdipoR1 and AdipoR2 proteins, as well as their C. elegans homolog PAQR-2, protect against cell membrane rigidification by exogenous saturated fatty acids by regulating phospholipid composition. Here, we show that mutations in the C. elegans gene acs-13 help to suppress the phenotypes of paqr-2 mutant worms, including their characteristic membrane fluidity defects. acs-13 encodes a homolog of the human...

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Identifiers

PMID: 31769755
DOI: 10.7554/eLife.47733
PMCID: PMC6901333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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