Article
Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans.
Science advances - 28 Nov 2025
Zhai Yile, Wang Tiantian, Han Jiangxue, Wu Mengxiao, Gong Meixi, Li Wenfei, Zhang Zhe
Abstract excerpt
Human female fertility declines markedly with age, a pattern mirrored in C. elegans fecundity. This shared vulnerability stems from evolutionarily conserved molecular pathways. A growing body of evidence links impaired proteostasis-the cell's ability to manage its proteins-to this age-related fertility drop in both species, although the underlying mechanisms are not fully understood. Here, we identify that LMD-3,...
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