Article

POI-associated LMD-3 mutation impairs B12-regulated lysosomal function and reproductive capacity in <i>C. elegans</i>

2025-10-15

Abstract excerpt

Reproductive longevity decline is a key feature of aging and premature ovarian insufficiency (POI). While proteostasis collapse is implicated in reproductive aging, the molecular link remains elusive. Here, we engineered the clinically relevant W690C mutation into C. elegans lmd-3 gene, the human NCOA7 ortholog, to establish a valuable in vivo POI model. The mutation severely compromises LMD-3 protein stability...

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Literature Corpus work: baaea31e-fa46-55e4-bc68-ccbf813d4271
DOI: 10.1101/2025.10.14.682338

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