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Disruption of the grid cell network in a mouse model of early Alzheimer’s disease

16 Feb 2022

Abstract excerpt

Early-onset familial Alzheimer's disease (AD) is marked by an aggressive buildup of amyloid beta (Aβ) proteins, yet the neural circuit operations impacted during the initial stages of Aβ pathogenesis remain elusive. Here, we report a coding impairment of the medial entorhinal cortex (MEC) grid cell network in the J20 transgenic mouse model of familial AD that over-expresses Aβ throughout the hippocampus and...

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PMID: 35173173
DOI: 10.1038/s41467-022-28551-x

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