Article

Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome

2026-01-30

Abstract excerpt

Memory impairment is a hallmark cognitive deficit in Rett syndrome (RTT). Yet, long-term memory deficits in RTT animal models remain poorly understood, largely due to the technical challenges inherent in tracking neural activity over extended periods. Here, we used longitudinal two-photon calcium imaging to follow the same population of hippocampal CA1 neurons as female RTT mice and their littermate controls forme...

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Literature Corpus work: b412e724-fbb7-55f2-b033-f212ff2a84ea
DOI: 10.64898/2026.01.29.702595

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