Article
Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit.
Neurobiology of disease - 1 Dec 2017
Angulo S L, Orman R, Neymotin S A, Liu L, Buitrago L, Cepeda-Prado E, Stefanov D, Lytton W W, Stewart M, Small S A, Duff K E, Moreno H
Abstract excerpt
The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. How the co-occurrence of these pathologies in the EC affects the hippocampal circuit remains unknown. Here we address this question by performing electrophysiological analyses of the EC circuit in mice that express mutant human amyloid precursor protein (hAPP) or tau...
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