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Article

Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.

The Journal of biological chemistry - 2 Jul 2010

Subramaniam Srinivasa, Mealer Robert G, Sixt Katherine M, Barrow Roxanne K, Usiello Alessandro, Snyder Solomon H

Abstract excerpt

We recently reported that the small G-protein Rhes has the properties of a SUMO-E3 ligase and mediates mutant huntingtin (mHtt) cytotoxicity. We now demonstrate that Rhes is a physiologic regulator of sumoylation, which is markedly reduced in the corpus striatum of Rhes-deleted mice. Sumoylation involves activation and transfer of small ubiquitin-like modifier (SUMO) from the thioester of E1 to the thioester of...

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Identifiers

PMID: 20424159
DOI: 10.1074/jbc.C110.127191
PMCID: PMC2898300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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