Article
Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.
Neuron - 21 Jan 2015
Lee John H, Tecedor Luis, Chen Yong Hong, Monteys Alex Mas, Sowada Matthew J, Thompson Leslie M, Davidson Beverly L
Abstract excerpt
Huntington's disease (HD) is caused by a polyglutamine tract expansion in huntingtin (HTT). Despite HTTs ubiquitous expression, there is early and robust vulnerability in striatum, the cause of which is poorly understood. Here, we provide evidence that impaired striatal mTORC1 activity underlies varied metabolic and degenerative phenotypes in HD brain and show that introducing the constitutively active form of...
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