Article

Frequent Whole-Genome Duplication Events Drive the Genomic Evolution of Triple-Negative Breast Cancer During Neoadjuvant Chemotherapy

2026-04-09

Abstract excerpt

<title>Abstract</title> <p>Background Triple-negative breast cancer (TNBC) is associated with poor survival rate and high genomic instability, generating complex tumour genomes. However, the processes that generate this complexity are poorly studied in longitudinal samples. Here, we study the temporal dynamics of TNBC somatic mutations, revealing major transitions in tumour genome evolution, from diagnostic biops...

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Literature Corpus work: 348d0b18-6ee5-55d5-a731-d4819f9c7bef
DOI: 10.21203/rs.3.rs-9212020/v1

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