Article

Frequent Whole-Genome Duplication Events Drive the Genomic Evolution of Triple-Negative Breast Cancer During Neoadjuvant Chemotherapy

2025-11-18

Abstract excerpt

<h4>Background</h4> Triple-negative breast cancer (TNBC) is associated with poor survival rate and high genomic instability, generating complex tumour genomes. However, the processes that generate this complexity are poorly studied in longitudinal samples. Here, we study the temporal dynamics of TNBC somatic mutations, revealing major transitions in tumour genome evolution, from diagnostic biopsies, through treat...

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Literature Corpus work: 50b7b84b-4567-5bd0-8c69-1fa12158a766
DOI: 10.1101/2025.11.17.688693

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