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Complex rearrangements fuel ER+ and HER2+ breast tumours

8 Jan 2025

Abstract excerpt

Breast cancer is a highly heterogeneous disease whose prognosis and treatment as defined by the expression of three receptors—oestrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2 (HER2; encoded by ERBB2)—is insufficient to capture the full spectrum of clinical outcomes and therapeutic vulnerabilities. Previously, we demonstrated that transcriptional and genomic profiles...

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PMID: 39779850
DOI: 10.1038/s41586-024-08377-x

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