Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency.

doi:10.1371/journal.pgen.1006853

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Article

Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency.

PLoS genetics - 1 Jun 2017

Kawazu Masahito, Kojima Shinya, Ueno Toshihide, Totoki Yasushi, Nakamura Hiromi, Kunita Akiko, Qu Wei, Yoshimura Jun, Soda Manabu, Yasuda Takahiko, Hama Natsuko, Saito-Adachi Mihoko, Sato Kazuhito, Kohsaka Shinji, Sai Eirin, Ikemura Masako, Yamamoto Shigeru, Ogawa Tomoko, Fukayama Masashi, Tada Keiichiro, Seto Yasuyuki, Morishita Shinichi, Hazama Shoichi, Shibata Tatsuhiro, Yamashita Yoshihiro, Mano Hiroyuki

Abstract excerpt

Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic options for this type of cancer. Here, we present comprehensive characterization of the genetic alterations in TNBC performed by high coverage whole genome sequencing...

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PMID: 28636652
DOI: 10.1371/journal.pgen.1006853
PMCID: PMC5500377

Genes

BRCA1
TGFA
MYC
NOTCH2
NOTCH3
PTEN

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