Article
Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic.
Genes - 19 Nov 2020
Rojas-Jiménez Ernesto, Mejía-Gómez Javier César, Díaz-Velásquez Clara, Quezada-Urban Rosalía, Martínez Gregorio Héctor, Vallejo-Lecuona Fernando, de la Cruz-Montoya Aldo, Porras Reyes Fany Iris, Pérez-Sánchez Víctor Manuel, Maldonado-Martínez Héctor Aquiles, Robles-Estrada Maybelline, Bargalló-Rocha Enrique, Cabrera-Galeana Paula, Ramos-Ramírez Maritza, Chirino Yolanda Irasema, Alonso Herrera Luis, Terrazas Luis Ignacio, Oliver Javier, Frecha Cecilia, Perdomo Sandra, Vaca-Paniagua Felipe
Abstract excerpt
Triple-negative breast cancer (TNBC) presents a marked diversity at the molecular level, which promotes a clinical heterogeneity that further complicates treatment. We performed a detailed whole exome sequencing profile of 29 Mexican patients with long follow-up TNBC to identify genomic alterations associated with overall survival (OS), disease-free survival (DFS), and pathologic complete response (PCR), with the...
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