Article

A novel precision medicine framework based on the excitation-inhibition imbalance model, for treatment of schizophrenia across the life span

2026-04-19

Abstract excerpt

<p>Schizophrenia is increasingly recognized as a neurodevelopmental disorder arising from excitation-inhibition (E/I) imbalance within cortical and subcortical networks. The E/I imbalance model posits that converging genetic, epigenetic and environmental influences act through glutamatergic (Glu) and gamma-aminobutyric acid (GABA)-ergic dysfunction, redox and immune dysregulation to destabilize neural E/I homeosta...

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Literature Corpus work: 07168d47-417c-5ddf-9c08-cc3c884a3c5d
DOI: 10.31234/osf.io/eqn4d_v1

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