Article

Overexpression of p53 Tumor Suppressor Protein in Porokeratosis

1994-02-01

Abstract excerpt

Background: p53 is a tumor suppressor nucleoprotein. Mutations of the p53 gene have been found in a variety of malignant neoplasms. Wild-type p53 has a short half-life, possibly only 20 to 30 minutes, and is not present in the nucleus at levels that are detectable with routine immunohistochemical techniques. Mutant p53 has a longer half-life, and is readily detectable with immunoperoxidase staining. Results: We st...

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Identifiers and source

Literature Corpus work: 3457ca59-8d24-55e2-944a-9028aca96a1a
DOI: 10.1001/archderm.1994.01690020053008

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