Article
Immunophenotypic analysis of the p53 gene in non-melanoma skin cancer and correlation with apoptosis and cell proliferation.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Mar 2005
Stratigos A J, Kapranos N, Petrakou E, Anastasiadou A, Pagouni A, Christofidou E, Petridis A, Papadopoulos O, Kokka E, Antoniou C, Georgala S, Katsambas A D
Abstract excerpt
BACKGROUND: Sunlight precipitates a series of genetic events that lead to the development of skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The p53 tumour suppressor gene, which plays a pivotal role in cell division and apoptosis, is frequently found mutated in sunlight-induced skin tumours. OBJECTIVE: To investigate the immunoreactivity of the p53 gene in non-melanoma skin...
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