Article
p53 expression in Langerhans cell histiocytosis.
Journal of pediatric hematology/oncology - 1 Jan 2000
Weintraub M, Bhatia K G, Chandra R S, Magrath I T, Ladisch S
Abstract excerpt
PURPOSE: Langerhans cell histiocytosis (LCH) is a disorder of unknown etiology involving the proliferation and accumulation of cells with the phenotype of a bone marrow-derived antigen-presenting cell of the skin, the Langerhans cell. We have studied p53 expression, an element in the control of c...
Topics
- Adolescent
- Child
- Child, Preschool
- Genes, p53
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- Infant
- Mutation
- Nuclear Proteins
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Tumor Suppressor Protein p53