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CXCR5 Down-regulation Alleviates Cognitive Dysfunction in a Mouse Model of Sepsis-associated Encephalopathy: Potential Role of Neuronal Autophagy and the p38MAPK/NF-κB/STAT3 Signaling Pathway

2021-06-01

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<title>Abstract</title> <p>BackgroundCognitive deficits are common in patients with sepsis. Previous studies in sepsis-associated encephalopathy (SAE) implicated the C-X-C chemokine receptor type (CXCR) 5. The present study used a mouse model of SAE to examine whether CXCR5 down-regulation could attenuate cognitive deficits.MethodsSepsis was induced in adult male C57BL/6J and <italic>CXCR5</italic><sup><italic>-/...

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Literature Corpus work
3417d569-05f8-54e2-b402-e22de7c9fe43
DOI
10.21203/rs.3.rs-531912/v1
Open publication

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CXCR5 Down-regulation Alleviates Cognitive Dysfunction in a Mouse Model of Sepsis-associated Encephalopathy: Potential Role of Neuronal Autophagy and the p38MAPK/NF-κB/STAT3 Signaling PathwayDOI 10.21203/rs.3.rs-531912/v1
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