Article
Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis.
Clinical science (London, England : 1979) - 17 Apr 2020
Michels Monique, Abatti Mariane, Vieira Andriele, Ávila Pricila, Goulart Amanda Indalécio, Borges Heloisa, Córneo Emily, Dominguini Diogo, Barichello Tatiana, Dal-Pizzol Felipe
Abstract excerpt
BACKGROUND: In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of microglial phenotypes in sepsis-induced brain dysfunction. METHODS: Wistar rats were submitted to sham or cecal ligation and perforation (CLP) and...
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