Back to search

Article

Activation of Liver X receptors alleviates neuropathic pain-induced cognitive dysfunction by modulating PI3K/AKT-mediated microglia polarization

2023-05-25

Abstract excerpt

<h4>Background: </h4> ： Cognitive dysfunction is a prevalent comorbidity in patients with chronic pain. Evidence suggested that activation of Liver X receptors (LXRs) plays a potential role in improving cognitive disorders in multiple central nervous diseases by modulating neuroinflammation and synaptic plasticity. In this study, we mainly investigated whether LXRs could reverse cognitive deficits induced by neuro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8605a6d0-32e6-51c4-b70c-dd08c3f3df3a
DOI
10.21203/rs.3.rs-2967465/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Activation of Liver X receptors alleviates neuropathic pain-induced cognitive dysfunction by modulating PI3K/AKT-mediated microglia polarizationDOI 10.21203/rs.3.rs-2967465/v1
P2X4R+ microglia drive neuropathic pain.Semantic proximity
P2RY6 activation aggravates NLRP3-dependent microglial pyroptosis via down-regulation of the PI3K/AKT pathway in a mouse model of intracerebral hemorrhageSemantic proximity
CXCR5 Down-regulation Alleviates Cognitive Dysfunction in a Mouse Model of Sepsis-associated Encephalopathy: Potential Role of Neuronal Autophagy and the p38MAPK/NF-κB/STAT3 Signaling PathwaySemantic proximity
Germacrone attenuates memory impairment, hippocampal inflammation, and neurological deficits induced by Lipopolysaccharide in miceSemantic proximity
Sciatic Nerve Stimulation Attenuates Intracranial Inflammation and Neuronal Injury in Acute Ischemic StrokeSemantic proximity
Investigating How Inflammation Involving NF-κB Signaling Disrupts the Genetic Architecture of Neurons/Neural Stem Cells and Fuels NeurodegenerationSemantic proximity
Targeting liver X receptors in inflammationSemantic proximity
FNDC5/irisin mediates hallmark brain alterations and cognitive impairment in acute intestinal injury/diseaseSemantic proximity
Contribution of TREM2 Signaling to the Development of Painful Diabetic Neuropathy by Mediating Microglial Polarization in MiceSemantic proximity
Linking Pain and Delirium via Microglial Activation: A Mouse Study Using BSEEG, Behavioral Assays, Immunohistochemistry, and RNA SequencingSemantic proximity
NLRP3 inhibition maintains microglia architecture and enhances behavioral recovery after traumatic brain injurySemantic proximity
Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout miceSemantic proximity
Select a neighboring publication to make it the new centre.