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Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche

2024-11-22

Abstract excerpt

Fibroblasts are present in all tissues and are crucial for maintaining tissue homeostasis. We previously identified fibroblasts marked by Dermatopontin ( Dpt ) but their role in supporting macrophage homeostasis remains unclear. Here, we generated novel mesenchymal lineage-restricted genetic tools to target Dpt expressing fibroblasts and elucidate their role in supporting skin macrophages. Transcriptional profi...

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Identifiers and source

Literature Corpus work
33e70636-0640-517f-8407-b56bbb2ce121
DOI
10.1101/2024.11.21.624708
Open publication

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Dermatopontin-expressing fibroblasts mediate an essential skin macrophage nicheDOI 10.1101/2024.11.21.624708
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