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Article

Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages

1 Jan 2024

Abstract excerpt

Rationale: Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, and skin fibrosis is one of distinguishing hallmarks in the pathogenesis. However, macrophage heterogeneity regulating skin fibrosis remain largely unknown. Methods: We established mouse disease model and performed single-cell RNA-sequencing (scRNA-seq) to resolve the dynamic and heterogenous...

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PMID: 38505612
DOI: 10.7150/thno.94121

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