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Article

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

22 Nov 2018

Abstract excerpt

During tissue repair, myofibroblasts produce extracellular matrix (ECM) molecules for tissue resilience and strength. Altered ECM deposition can lead to tissue dysfunction and disease. Identification of distinct myofibroblast subsets is necessary to develop treatments for these disorders. We analyzed profibrotic cells during mouse skin wound healing, fibrosis, and aging and identified distinct subpopulations of...

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PMID: 30467144
DOI: 10.1126/science.aar2971

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