Article
Understanding the impact of fibroblast heterogeneity on skin fibrosis.
Disease models & mechanisms - 15 Jun 2020
Griffin Michelle F, desJardins-Park Heather E, Mascharak Shamik, Borrelli Mimi R, Longaker Michael T
Abstract excerpt
Tissue fibrosis is the deposition of excessive extracellular matrix and can occur as part of the body's natural wound healing process upon injury, or as a consequence of diseases such as systemic sclerosis. Skin fibrosis contributes to significant morbidity due to the prevalence of injuries resulting from trauma and burn. Fibroblasts, the principal cells of the dermis, synthesize extracellular matrix to maintain...
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