Article

Interleukin-16/STAT6 recruits CBP/p300 to upregulate TIMP-3 and promote atherosclerotic plaque stability

2023-05-24

Abstract excerpt

<h4>Background</h4> Atherosclerotic plaque rupture increases the risk of ischemic heart disease and stroke and commonly causes sudden death. High levels of circulating or intraplaque interleukin 16 (IL-16) are clinically associated with a reduced incidence of cardiovascular events. Here, we investigated the effects of IL-16 on plaque phenotypic modification and identified the molecules involved in smooth muscle c...

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Identifiers and source

Literature Corpus work: 33cb1efe-c504-55a9-81cf-ec93c36fa199
DOI: 10.1101/2023.05.23.542025

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