PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.

doi:10.1161/CIRCRESAHA.119.316063

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Article

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.

Circulation research - 28 Feb 2020

Rykaczewska Urszula, Suur Bianca E, Röhl Samuel, Razuvaev Anton, Lengquist Mariette, Sabater-Lleal Maria, van der Laan Sander W, Miller Clint L, Wirka Robert C, Kronqvist Malin, Gonzalez Diez Maria, Vesterlund Mattias, Gillgren Peter, Odeberg Jacob, Lindeman Jan H, Veglia Fabrizio, Humphries Steve E, de Faire Ulf, Baldassarre Damiano, Tremoli Elena, Lehtiö Janne, Hansson Göran K, Paulsson-Berne Gabrielle, Pasterkamp Gerard, Quertermous Thomas, Hamsten Anders, Eriksson Per, Hedin Ulf, Matic Ljubica

Abstract excerpt

RATIONALE: PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens. OBJECTIVE: Here, we applied a systems biology approach to gain deeper insights into the PCSK6 role in normal...

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PMID: 31893970
DOI: 10.1161/CIRCRESAHA.119.316063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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