Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-16 upregulates tissue inhibitor of metalloproteinase 3 to promote atherosclerotic plaque stability.

Journal of translational medicine - 19 Jan 2026

He Hui, Ding Meng, Zhu Yuan, Jiang Tianyu, Dong Doudou, Xu Xiaoting, Yu Wenfeng, Ou Hailong

Abstract excerpt

BACKGROUND: High levels of circulating interleukin (IL)-16 are associated with a reduced incidence of cardiovascular events. The disruption of atherosclerotic plaques commonly causes myocardial infarction and stroke. In this study, we investigated the effects of IL-16 on phenotypic modification of plaques. METHODS: Mice with deficiencies in IL-16 and apolipoprotein E (IL16-/-ApoE-/-) were generated and used for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Interleukin-16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Myocytes, Smooth Muscle

Share to p300-CBP Transcription Factors

Share to Plaque, Atherosclerotic

Share to STAT6 Transcription Factor

Share to Tissue Inhibitor of Metalloproteinase-3

Source

Open in PubMed Open full text

Identifiers

PMID: 41555435
DOI: 10.1186/s12967-025-07663-0
PMCID: PMC12903335

Genes

STAT6
CD4
IL16
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-16 upregulates tissue inhibitor of metalloproteinase 3 to promote atherosclerotic plaque stability.PMID 41555435Read ↗

Interleukin-16/STAT6 recruits CBP/p300 to upregulate TIMP-3 and promote atherosclerotic plaque stabilitySemantic proximity Read ↗

PI16 is a shear stress and inflammation-regulated inhibitor of MMP2.Semantic proximity Read ↗

Overexpression of CXCL16 promotes a vulnerable plaque phenotype in Apolipoprotein E-Knockout Mice.Semantic proximity Read ↗

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.Semantic proximity Read ↗

CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization.Semantic proximity Read ↗

PRDM16 controls smooth muscle cell fate in atherosclerosisSemantic proximity Read ↗

CD27⁺ γδ T Cells Drive Plaque Instability in Advanced Atherosclerosis: Targeting CXCR3 for Therapeutic InterventionSemantic proximity Read ↗

SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathwaySemantic proximity Read ↗

ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation.Semantic proximity Read ↗

A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels.Semantic proximity Read ↗

Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.Semantic proximity Read ↗

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.