Article
A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels.
The Journal of biological chemistry - 7 Nov 2014
Moll Herwig P, Lee Andy, Minussi Darlan C, da Silva Cleide G, Csizmadia Eva, Bhasin Manoj, Ferran Christiane
Abstract excerpt
IFNγ signaling in endothelial (EC) and smooth muscle cells (SMC) is a key culprit of pathologic vascular remodeling. The impact of NF-κB inhibitory protein A20 on IFNγ signaling in vascular cells remains unknown. In gain- and loss-of-function studies, A20 inversely regulated expression of IFNγ-induced atherogenic genes in human EC and SMC by modulating STAT1 transcription. In vivo, inadequate A20 expression in...
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