Article
CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization.
International immunopharmacology - 1 Aug 2026
Yao Guoqing, Luan Tiankuo, Song Daqiang, Liu Guojing, Hu Xuemei, Feng Yangyang, Liang Rui, Zhao Yu, Liu Hong
Abstract excerpt
BACKGROUND: Carotid plaque instability is a major determinant of ischemic stroke and is characterized by heightened inflammation and structural remodeling of the vessel wall. Although macrophages and vascular smooth muscle cells (VSMCs) are central to plaque vulnerability, the mechanisms coordinating immune activation with vascular remodeling remain incompletely understood. METHODS: Bulk transcriptomic data from...
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