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lnterleukin-16: The Ins and Outs of Regulating T-Cell Activation

1 Jan 2008

Abstract excerpt

Intcrleukin-16 (IL-16) was originally identified in 1980 as the first-described T-cell chemoattractant. Since that time, the protein has been cloned, sequenced, and characterized in terms of expression and biologic function for regulating inflammation. Generated as a precursor molecule, IL-16 is cleaved by caspase-3, yielding pro-IL-16 and the secreted (mature) portion. Both components of IL-16 are now known to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19265505
DOI: 10.1615/critrevimmunol.v28.i6.10

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