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Article

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.

Cardiovascular research - 1 Jan 2018

Brauner Susanna, Jiang Xintong, Thorlacius Gudny Ella, Lundberg Anna M, Östberg Therese, Yan Zhong-Qun, Kuchroo Vijay K, Hansson Göran K, Wahren-Herlenius Marie

Abstract excerpt

Aims: Patients with hyperlipidemia are at risk of atherosclerosis, but not all develop cardiovascular disease, highlighting the importance of other risk factors such as inflammation. Both the innate and adaptive arms of the immune system have been suggested in the initiation and propagation of plaque formation. Tri-partite motif (TRIM) 21 is a regulator of tissue inflammation and pro-inflammatory cytokine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29016728
DOI: 10.1093/cvr/cvx181

Genes

TRIM21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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