Article

Kinship estimation bias carries over to heritability estimation bias using variance components

2025-05-15

Abstract excerpt

Heritability is a fundamental parameter of diseases and other traits, quantifying the contribution of genetics to that trait. Kinship matrices, also known as Genetic Relatedness Matrices or “GRMs”, are required for heritability estimation with variance components models. However, the most common “standard” kinship estimator employed by GCTA and other approaches, can be severely biased in structured populations. In...

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Literature Corpus work: 33c82bc6-6782-585e-94a4-5df9bf807973
DOI: 10.1101/2025.05.13.653659

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