Article
Genomic kinship construction to enhance genetic analyses in the human connectome project data.
Human brain mapping - 1 Apr 2019
Kochunov Peter, Donohue Brian, Mitchell Braxton D, Ganjgahi Habib, Adhikari Bhim, Ryan Meghann, Medland Sarah E, Jahanshad Neda, Thompson Paul M, Blangero John, Fieremans Els, Novikov Dmitry S, Marcus Daniel, Van Essen David C, Glahn David C, Elliot Hong L, Nichols Thomas E
Abstract excerpt
Imaging genetic analyses quantify genetic control over quantitative measurements of brain structure and function using coefficients of relationship (CR) that code the degree of shared genetics between subjects. CR can be inferred through self-reported relatedness or calculated empirically using genome-wide SNP scans. We hypothesized that empirical CR provides a more accurate assessment of shared genetics than...
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