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Article

Genetic association models are robust to common population kinship estimation biases.

Genetics - 4 May 2023

Hou Zhuoran, Ochoa Alejandro

Abstract excerpt

Common genetic association models for structured populations, including principal component analysis (PCA) and linear mixed-effects models (LMMs), model the correlation structure between individuals using population kinship matrices, also known as genetic relatedness matrices. However, the most common kinship estimators can have severe biases that were only recently determined. Here we characterize the effect of...

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PMID: 36843304
DOI: 10.1093/genetics/iyad030
PMCID: PMC10474929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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