Kinship estimation bias carries over to heritability estimation bias using variance components.

Abstract excerpt

Heritability is a fundamental parameter of diseases and other traits, quantifying the contribution of genetics to that trait. Kinship matrices are required for heritability estimation with variance components models. However, the most common "standard" kinship estimator employed by Genome-wide Complex Trait Analysis and other approaches, can be severely biased in structured populations. In this study, we...

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