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Article

Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data.

PLoS genetics - 1 Sept 2017

Dou Jinzhuang, Sun Baoluo, Sim Xueling, Hughes Jason D, Reilly Dermot F, Tai E Shyong, Liu Jianjun, Wang Chaolong

Abstract excerpt

Knowledge of biological relatedness between samples is important for many genetic studies. In large-scale human genetic association studies, the estimated kinship is used to remove cryptic relatedness, control for family structure, and estimate trait heritability. However, estimation of kinship is challenging for sparse sequencing data, such as those from off-target regions in target sequencing studies, where...

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PMID: 28961250
DOI: 10.1371/journal.pgen.1007021
PMCID: PMC5636172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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