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Article

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans.

Oncotarget - 8 Dec 2015

Kumar Neeraj, Jain Vaibhav, Singh Anupama, Jagtap Urmila, Verma Sonia, Mukhopadhyay Arnab

Abstract excerpt

Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is conserved. DAF-16 predominantly acts as a transcriptional activator and binding within the 0.5 kb promoter-proximal...

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Share to Caenorhabditis elegans Proteins
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Box Protein O3

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Share to Receptor, Insulin

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Source

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Identifiers

PMID: 26539642
DOI: 10.18632/oncotarget.6282
PMCID: PMC4747164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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