Article

Endogenous DAF-16 Spatiotemporal Activity Quantitatively Predicts Lifespan Extension Induced by Dietary Restriction

2021-12-21

Abstract excerpt

<h4>Summary</h4> In many organisms, dietary restriction (DR) leads to lifespan extension through the activation of cell protection and pro-longevity gene expression programs. In the nematode C. elegans , the DAF-16 transcription factor is a key aging regulator that governs the Insulin/IGF-1 signaling pathway and undergoes translocation from the cytoplasm to the nucleus of cells when animals are exposed to food l...

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Literature Corpus work: ded75beb-26a2-5d08-bf1d-dfad63ba2f44
DOI: 10.1101/2021.12.20.473576

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