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Article

TLR4 Activates the β-catenin Pathway to Cause Intestinal Neoplasia

14 May 2013

Abstract excerpt

Colonic bacteria have been implicated in the development of colon cancer. We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for bacterial lipopolysaccharide (LPS), is over-expressed in humans with colitis-associated cancer. Genetic epidemiologic data support a role for TLR4 in sporadic colorectal cancer (CRC) as well, with over-expression favoring more aggressive disease. The goal of...

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PMID: 23691015
DOI: 10.1371/journal.pone.0063298

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