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Article

Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.

Cancer research - 1 May 2013

Xu Changxin, Reichert Ethan C, Nakano Tomoyuki, Lohse Mariah, Gardner Alison A, Revelo Mónica P, Topham Matthew K, Stafforini Diana M

Abstract excerpt

Platelet-activating factor (PAF) is a naturally occurring phospholipid that mediates diverse effects such as physiological and pathological inflammation, immunosuppression, and cancer. Several lines of evidence support both positive and negative roles for PAF in carcinogenesis. PAF stimulates cell growth, oncogenic transformation, and metastasis, but can also limit proliferation and induce apoptosis. The...

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Source

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Identifiers

PMID: 23361301
DOI: 10.1158/0008-5472.CAN-12-2374
PMCID: PMC3643996

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.PMID 23361301Read ↗

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Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.Semantic proximity Read ↗

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cellsSemantic proximity Read ↗

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Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancersSemantic proximity Read ↗

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