Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice.

Molecular cancer research : MCR - 1 Jan 2012

Liu Pengyuan, Lu Yan, Liu Hongbo, Wen Weidong, Jia Dongmei, Wang Yian, You Ming

Abstract excerpt

To identify the genetic determinants of colon tumorigenesis, 268 male mice from 33 inbred strains derived from different genealogies were treated with azoxymethane (AOM; 10 mg/kg) once a week for six weeks to induce colon tumors. Tumors were localized exclusively within the distal colon in each of the strains examined. Inbred mouse strains exhibit a large variability in genetic susceptibility to AOM-induced colon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Genetic Loci

Share to Mice, Inbred C3H

Share to Mice, Inbred CBA

Share to Mice, Inbred DBA

Share to Neoplasms, Multiple Primary

Source

Identifiers

PMID: 22127497
DOI: 10.1158/1541-7786.MCR-10-0540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice.PMID 22127497Read ↗

Genetic control of susceptibility to carcinogen-induced colorectal cancer in mice: the Ccs3 and Ccs5 loci regulate different aspects of tumorigenesis.Semantic proximity Read ↗

Five new mouse susceptibility to colon cancer loci, Scc11-Scc15.Semantic proximity Read ↗

Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross.Semantic proximity Read ↗

Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.Semantic proximity Read ↗

Genetic and microbial determinants of azoxymethane-induced colorectal tumor susceptibility in Collaborative Cross mice and their implication in human cancer.Semantic proximity Read ↗

Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.Semantic proximity Read ↗

Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer.Semantic proximity Read ↗

Genetic and microbial determinants of azoxymethane-induced colorectal tumor susceptibility in Collaborative Cross mice and their implication in human cancerSemantic proximity Read ↗

Mapping Genetic Modifiers of Polyp Formation in Smad4-Deficient Juvenile Polyposis Using the Collaborative Cross Mouse Population.Semantic proximity Read ↗

Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat.Semantic proximity Read ↗

Genomic variants in mouse model induced by azoxymethane and dextran sodium sulfate improperly mimic human colorectal cancer.Semantic proximity Read ↗

A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.