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Article

Expression of <i>Pla2g2a</i> prevents carcinogenesis in <i>Muc2</i>‐deficient mice

16 Oct 2008

Abstract excerpt

Goblet cell depletion and down-regulation of MUC2 expression are observed in a significant percentage of human non-mucinous colorectal adenocarcinomas. Direct evidence for the role of MUC2 in gastrointestinal tumor formation was demonstrated by a knockout of Muc2 in mice that resulted in the development of adenocarcinomas in the small and large intestine. The secretory phospholipase Pla2g2a is a protein that...

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PMID: 19037975
DOI: 10.1111/j.1349-7006.2008.00924.x

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