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Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon

1 Oct 2006

Abstract excerpt

The majority of colon cancers develop from pre-existing adenomas. We analyzed the expression profiles in the sequence of normal colon crypts, adenomas and early-stage carcinomas using microdissected cells from tubular adenomas with foci of malignant transformation. Differentially expressed genes were detected between normal-adenoma and adenoma-carcinoma, and were grouped according to the patterns of expression...

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PMID: 16969489
DOI: 10.3892/or.16.4.747

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