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Article

Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice.

Carcinogenesis - 1 Aug 2014

Zeineldin Maged, Miller Matthew A, Sullivan Ruth, Neufeld Kristi L

Abstract excerpt

Mutation of tumor suppressor adenomatous polyposis coli (APC) initiates most colorectal cancers and chronic colitis increases risk. APC is a nucleo-cytoplasmic shuttling protein, best known for antagonizing Wnt signaling by forming a cytoplasmic complex that marks β-catenin for degradation. Using our unique mouse model with compromised nuclear Apc import (Apc(mNLS)), we show that Apc(mNLS/mNLS) mice have...

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Source

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Identifiers

PMID: 24894865
DOI: 10.1093/carcin/bgu121
PMCID: PMC4123651

Genes

APC
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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