Article

Tbxl represses <i>Mef2c</i> gene expression by inducing histone 3 deacetylation of the anterior heart field enhancer

2017-02-28

Abstract excerpt

The TBX1 gene is haploinsufficient in the 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome. Tbx1 can activate and repress transcription and previous work has shown that one of its functions is to negatively modulate cardiomyocyte differentiation. Tbx1 occupies the anterior heart field (AHF) enh...

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Literature Corpus work: 3351accb-c472-53fb-8261-83a594946867
DOI: 10.1101/112144

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