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Article

Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer

30 Aug 2018

Abstract excerpt

ABSTRACT The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome. Tbx1 can activate and repress transcription, and previous work has shown that one of its functions is to negatively modulate cardiomyocyte differentiation. Tbx1 occupies the anterior heart field...

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PMID: 30166330
DOI: 10.1242/dmm.029967

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Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancerPMID 30166330Read ↗

Tbxl represses <i>Mef2c</i> gene expression by inducing histone 3 deacetylation of the anterior heart field enhancerSemantic proximity Read ↗

Tbx1 is a negative modulator of Mef2c.Semantic proximity Read ↗

Dysregulation of TBX1 dosage in the anterior heart field results in congenital heart disease resembling the 22q11.2 duplication syndrome.Semantic proximity Read ↗

Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiationSemantic proximity Read ↗

Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.Semantic proximity Read ↗

Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndromeSemantic proximity Read ↗

Brg1 modulates enhancer activation in mesoderm lineage commitment.Semantic proximity Read ↗

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.Semantic proximity Read ↗

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of masticationSemantic proximity Read ↗

<i>Mef2c</i>is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic developmentSemantic proximity Read ↗

Chromatin and transcriptional response to loss of TBX1 in early differentiation of mouse cellsSemantic proximity Read ↗

Tbx1 regulates extracellular matrix-cell interactions in the second heart fieldSemantic proximity Read ↗

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