Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.

doi:10.1016/j.celrep.2023.112180

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Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.

Cell reports - 28 Mar 2023

Bogetofte Helle, Ryan Brent J, Jensen Pia, Schmidt Sissel I, Vergoossen Dana L E, Barnkob Mike B, Kiani Lisa N, Chughtai Uroosa, Heon-Roberts Rachel, Caiazza Maria Claudia, McGuinness William, Márquez-Gómez Ricardo, Vowles Jane, Bunn Fiona S, Brandes Janine, Kilfeather Peter, Connor Jack P, Fernandes Hugo J R, Caffrey Tara M, Meyer Morten, Cowley Sally A, Larsen Martin R, Wade-Martins Richard

Abstract excerpt

Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic risk factor for Parkinson's disease (PD). To understand GBA-related disease mechanisms, we use a multi-part-enrichment proteomics and post-translational modification (PTM) workflow, identifying large numbers of dysregulated proteins and PTMs in heterozygous GBA-N370S PD patient induced pluripotent stem cell (iPSC) dopamine...

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PMID: 36870058
DOI: 10.1016/j.celrep.2023.112180

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